Robert B Diasio Selected Research

Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)

5/2014	Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity.
9/2009	Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survival.
11/2007	Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
7/2007	Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase.
9/2006	Dihydropyrimidine dehydrogenase deficiency in an Indian population.
9/2006	Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer.
1/2006	The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.
12/2005	Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients.
12/2005	Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects.
12/2005	Phase I study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: expression analysis of genes related to outcome.

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Robert B Diasio Research Topics

Disease

43	Neoplasms (Cancer) 01/2021 - 02/2002
12	Dihydropyrimidine Dehydrogenase Deficiency 06/2022 - 03/2002
8	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 11/2003
8	Adenocarcinoma 01/2020 - 04/2004
8	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017 - 02/2002
6	Breast Neoplasms (Breast Cancer) 12/2012 - 03/2002
5	Diarrhea 01/2020 - 12/2005
4	Colonic Neoplasms (Colon Cancer) 01/2020 - 06/2014
3	Exanthema (Rash) 07/2016 - 01/2007
3	Mucositis 01/2014 - 01/2007
2	Leukopenia 01/2020 - 09/2006
2	Neutropenia 01/2020 - 08/2010
2	Fatigue 01/2020 - 07/2010
2	Lung Neoplasms (Lung Cancer) 01/2019 - 05/2015
2	Thrombocytopenia (Thrombopenia) 07/2016 - 09/2007
2	Cytopenia 01/2014 - 01/2007
2	Neoplasm Metastasis (Metastasis) 01/2007 - 01/2006
2	Glioblastoma (Glioblastoma Multiforme) 12/2006 - 10/2002
2	Peripheral Nervous System Diseases (PNS Diseases) 10/2006 - 09/2004
1	Rectal Neoplasms (Rectal Cancer) 01/2020
1	Margins of Excision 04/2019
1	Gilbert Disease 10/2016
1	Hyperbilirubinemia 10/2016
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 10/2016
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2016
1	Poisoning 07/2016
1	Pancytopenia 07/2016
1	Adenocarcinoma of Lung 05/2015
1	Stomatitis 01/2014
1	Malignant Pleural Effusion 01/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2013
1	Infections 12/2009
1	Asthma (Bronchial Asthma) 12/2009
1	Liver Diseases (Liver Disease) 12/2009
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 10/2009
1	Cardiotoxicity 01/2008
1	Vomiting 03/2007
1	Hypokalemia 03/2007
1	Ascites 03/2007

Drug/Important Bio-Agent (IBA)

30	Fluorouracil (Carac)FDA LinkGeneric 06/2022 - 03/2002
15	Capecitabine (Xeloda)FDA Link 01/2021 - 10/2002
12	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 05/2014 - 11/2003
7	Proteins (Proteins, Gene)FDA Link 02/2014 - 02/2002
7	Messenger RNA (mRNA)IBA 09/2009 - 02/2002
7	Thymidine PhosphorylaseIBA 09/2009 - 10/2002
6	Pharmaceutical PreparationsIBA 01/2021 - 11/2003
6	EnzymesIBA 07/2016 - 02/2002
6	UracilIBA 05/2014 - 12/2005
3	Leucovorin (Folinic Acid)FDA Link 01/2020 - 07/2010
3	Estrogen ReceptorsIBA 12/2012 - 10/2010
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007 - 10/2002
2	RNA (Ribonucleic Acid)IBA 05/2015 - 02/2006
2	Cetuximab (Erbitux)FDA Link 12/2014 - 01/2006
2	Hormones (Hormone)IBA 12/2012 - 10/2010
2	Progesterone Receptors (Progesterone Receptor)IBA 10/2011 - 10/2011
2	edotecarin (J 107088)IBA 08/2010 - 05/2005
2	Antineoplastic Agents (Antineoplastics)IBA 10/2009 - 12/2005
2	Thymidylate SynthaseIBA 12/2006 - 09/2006
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2005 - 05/2005
2	ProdrugsIBA 09/2004 - 10/2002
2	eniluracilIBA 11/2003 - 03/2002
1	Genetic Markers (Genetic Marker)IBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2020
1	Bevacizumab (Avastin)FDA Link 01/2020
1	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 10/2016
1	Uridine Diphosphate (UDP)IBA 10/2016
1	Imatinib Mesylate (Gleevec)FDA Link 10/2016
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2016
1	AntidotesIBA 07/2016
1	uridine triacetateIBA 07/2016
1	MicroRNAs (MicroRNA)IBA 06/2014
1	3' Untranslated Regions (3' UTR)IBA 06/2014
1	DNA (Deoxyribonucleic Acid)IBA 06/2014
1	human ERBB2 proteinIBA 02/2014
1	pyrimidineIBA 03/2013
1	Docetaxel (Taxotere)FDA Link 01/2013
1	Epidermal Growth Factor (EGF)IBA 10/2011
1	Estrogens (Estrogen)FDA Link 10/2011
1	Vorinostat FDA Link 07/2010
1	CarbohydratesIBA 12/2009
1	AlkanesIBA 12/2009
1	FructoseIBA 12/2009
1	Lactose FDA LinkGeneric 12/2009
1	Histone Deacetylases (Histone Deacetylase)IBA 10/2009
1	ChromatinIBA 10/2009
1	Histones (Histone)IBA 10/2009
1	Histone Deacetylase InhibitorsIBA 10/2009
1	Gemcitabine FDA Link 03/2008
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 07/2007

Therapy/Procedure

14	Drug Therapy (Chemotherapy) 06/2022 - 03/2002
9	Therapeutics 06/2022 - 01/2006
5	Radiotherapy 09/2009 - 10/2002
2	Adjuvant Chemotherapy 01/2019 - 04/2004
2	Precision Medicine 11/2017 - 01/2017
1	Secondary Prevention 01/2020
1	Colostomy 01/2020
1	Neoadjuvant Therapy 01/2020
1	Oral Administration 10/2016
1	Proton Therapy 10/2012